Tag: UMI

AccuGenomics at the AACR – Novel NGS Analysis of Actionable Mutations in ctDNA: Improved QC and Fewer Reads

Identification of actionable mutations in circulating tumor DNA (ctDNA) enables gene-targeted therapy of solid tumors based on a simple blood test. NGS methods that attach a unique molecular identifier (UMI) to each DNA molecule control for sequencing technical error and thereby reduce variant allele fraction (VAF) limit of detection (LOD) to <0.01% at a cost of 10-20-fold higher sequencing requirement.…

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